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目的研究维吾尔族健康志愿者单次静脉滴注盐酸头孢吡肟(第4代头孢菌素类抗生素)后的药代动力学,并与汉族进行比较。方法健康维吾尔族和汉族志愿者各10名,男女各半,单次静脉滴注盐酸头孢吡肟1.0g,定时采血,用RP-HPLC法测定头孢吡肟的血药浓度,用DAS2.0软件进行数据处理,用SPSS11.5软件进行统计分析。结果维吾尔族和汉族健康志愿者主要药代动力学参数:Cmax分别为(83.19±10.31)、(68.75±10.41)mg.L-1;t1/2β分别为(2.06±0.33)、(1.97±0.20)h;AUC(0-10.5)分别为(162.00±24.22)、(136.89±23.02)mg.h.L-1;AUC(0-∞)分别为(165.58±24.49)、(139.69±23.78)mg.h.L-1。结论维、汉2民族的种族差异对头孢吡肟的药代动力学无影响。
Objective To study the pharmacokinetics of single-dose intravenous cefepime hydrochloride (fourth-generation cephalosporin antibiotics) in healthy Uygur volunteers compared with Han nationality. Methods A total of 10 healthy volunteers were enrolled in this study. The male and female volunteers were divided into two groups. Male and female were divided into two groups. 1.0 g of cefepime hydrochloride was injected intravenously and blood was collected regularly. Plasma concentration of cefepime was determined by RP-HPLC. Data processing, using SPSS11.5 software for statistical analysis. Results The main pharmacokinetic parameters of healthy volunteers in Uygur and Han nationality were Cmax (83.19 ± 10.31) and (68.75 ± 10.41) mg.L-1, respectively. The t1 / 2β were (2.06 ± 0.33) and (1.97 ± 0.20 ) h; AUC (0-10.5) were (162.00 ± 24.22) and (136.89 ± 23.02) mg.hL-1, respectively; AUC (0-∞) were (165.58 ± 24.49) and (139.69 ± 23.78) -1. Conclusion Race differences between Victoria and Han 2 ethnic groups have no effect on the pharmacokinetics of cefepime.