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二羟丙氧甲基鸟嘌岭(DHPG),在组织培养中对单纯疱疹病毒Ⅰ型(HSV-1)KOS株抑制50%空斑形成的浓度(IC_(50))为0.1μg/ml。DHPG与环胞苷联合应用的抗HSV活性呈协同作用;DHPG分别与无环鸟苷、酞丁安合用有相加作用。0.1和0.05%DHPG溶液滴眼对家兔实验性浅层单纯疱疹病毒角膜炎有显著治疗作用,浓度降低至0.025和0.0l%无明显疗效。对实质层型单疱角膜炎,0.1%DHPG溶液滴眼治疗有效。
Dihydroxy-propoxymethylguanine (DHPG). The concentration (IC 50) of 50% inhibition of plaque formation on herpes simplex virus type 1 (HSV-1) KOS strain in tissue culture was 0.1 μg / ml. The anti-HSV activity of DHPG in combination with cytidine has a synergistic effect; DHPG has an additive effect with acyclovir and teiadinan respectively. Eye drops of 0.1 and 0.05% DHPG solution had significant therapeutic effect on rabbits with experimental herpes simplex virus keratitis. No significant effect was found when the concentration was reduced to 0.025 and 0.0l%. On the substantive herpes simplex keratitis, 0.1% DHPG solution eye drops effective.