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目的 探讨干扰素 α联合聚肌胞治疗慢性乙型肝炎的疗效。方法选择 6 0例慢性乙型肝炎患者 ,随机分 2组接受治疗 ,30例为干扰素 α联合聚肌胞治疗 ,B组 (30例 )单用干扰素 α治疗 ,观察治疗前后血清及病原学指标变化。结果 发现HBeAg及HBVDNA阴转率A组分别为 6 6 .7% ,70 .0 % ;B组 4 0 .0 % ,5 0 .0 %。两组有显著性差异 (P <0 .0 5 )。结论 干扰素 α联合聚肌胞 ,具有协同效果 ,疗效优于单用干扰素 α。
Objective To investigate the therapeutic effect of interferon α combined with poly-cytosols on chronic hepatitis B patients. Methods Sixty patients with chronic hepatitis B were selected and randomly divided into two groups. 30 patients were treated with interferon alfa combined with polymyositis, and group B (30 patients) were treated with interferon alpha only. Serum and etiology Indicator changes. The results showed that the negative conversion rate of HBeAg and HBVDNA in group A were 66.7% and 70.0%, respectively; in group B 40.0% and 50.0%. There was a significant difference between the two groups (P <0.05). Conclusions Interferon α combined with polymyosin has a synergistic effect and is superior to interferon α alone.