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目的观察稳定期慢性阻塞性肺病(COPD)患者戒烟5年后肺功能的变化。方法选择66名稳定期COPD患者为研究对象,并进行随机分组,肺功能检查按常规方法进行。结果戒烟者在5年后随访肺功能与不戒烟者肺功能相比,肺活量(VC)、用力肺活量(FVC)、1秒钟用力呼气容积(FEV1)年下降值差异有统计学意义(P<0.01);呼气峰流速(PEF)年下降值差异有统计学意义(P<0.05);残气量(RV)的年增加值差异有统计学意义(P<0.01)。一秒钟用力呼气容积与用力肺活量比值(FEV1.0/FVC)、最大通气量(MVV)、最大呼气中期流量(MMEF)、功能残气量(FRC)、肺总量(TLC)、残气量/肺总量(RV/TLC)也有一定的改变,但变化值未达到统计学意义。结论通过随访研究发现稳定期COPD患者戒烟后可延缓肺功能的下降,并建议尽早戒烟。
Objective To observe the changes of lung function in patients with stable chronic obstructive pulmonary disease (COPD) after quitting smoking for 5 years. Methods Sixty-six patients with stable COPD were selected as study subjects and randomized. Pulmonary function tests were performed according to routine methods. Results After 5 years of follow-up, lung function was significantly decreased in patients with lung function (VC), forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) <0.01). There was significant difference between the annual decline of peak expiratory flow velocity (PEF) (P <0.05) and the annual increase of residual volume (RV) (P <0.01). The ratio of FEV1.0 / FVC, MVV, MMEF, FRC, TLC, Volume of air / total lung volume (RV / TLC) also have some changes, but the changes did not reach statistical significance. Conclusion Through follow-up study found that patients with stable COPD after quitting can delay the decline in lung function, and recommended early quit smoking.