卵巢癌是妇科常见的恶性肿瘤,病死率居妇科肿瘤之首。近年来,尽管肿瘤细胞减灭术的广泛开展以及以顺铂为主联合化疗的应用,然而化疗耐药严重影响了卵巢癌患者的化疗效果和生存质量,使患者5年生存率大大下降。据美国癌症协会估计,90%以上因肿瘤死亡患者在不同程度上受到耐药的影响〔1〕。人体细胞都有自我保护机制,肿瘤细胞也不例外,所以它对杀死自己的各种化疗药物也有抑制作用,即防止其对自身的损害〔2〕。耐药性产生的原因非常复杂,不同药物其 Ovarian cancer is a common gynecological malignancy, mortality in the first gynecological cancer. In recent years, despite the extensive application of cytoreductive surgery and cisplatin-based chemotherapy, chemotherapy resistance has seriously affected the chemotherapy effect and quality of life in ovarian cancer patients, resulting in a significant reduction in 5-year survival rate. According to the American Cancer Society, more than 90% of patients who die from cancer are affected to varying degrees by drug resistance [1]. Human cells have self-protection mechanism, tumor cells are no exception, so it also kills their own various chemotherapy drugs also have an inhibitory effect, that is, to prevent its own damage 〔2〕. The causes of resistance are very complex, different drugs