在酒精性肝病发病过程中存在诱导型一氧化氮合酶的表达增强,生成大量一氧化氮,在氧化应激的状态下与活性氧反应生成过氧化亚硝酸根离子,从而引发硝化应激,通过介导蛋白质、核酸等的硝化,影响细胞信号转导通路,最终影响细胞的代谢等功能及细胞凋亡,参与酒精性肝病的发病。本文旨在阐述硝化应激在酒精性肝病发病机制中可能发挥的作用。 In the pathogenesis of alcoholic liver disease, the expression of inducible nitric oxide synthase is enhanced, a large amount of nitric oxide is generated, which reacts with reactive oxygen species to generate peroxynitrite ion under the state of oxidative stress, thereby causing nitrification stress, By mediating the nitration of proteins and nucleic acids, it influences the cell signal transduction pathway, ultimately affecting cell metabolism and apoptosis, and is involved in the pathogenesis of alcoholic liver disease. This article aims to explain the possible role of nitrification stress in the pathogenesis of alcoholic liver disease.