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整合素(integrin)是近年来各学科尤其是肿瘤学重点研究的一种细胞黏附分子,它结构及功能复杂多样,在肿瘤的发生与进展过程中起到重要作用,是未来探求肿瘤生长机制及制定靶点治疗手段的方向之一。本文就整合素的研究现状作一综述,并重点针对其在膀胱肿瘤中的研究进展进行总结。 1 整合素的分子结构整合素(integrin)是一大类跨膜蛋白家族,家族成员均为由α、β两个亚基通过非共价键连接而成的异二聚体,可介导细胞与细胞外基质(extracellular matrix,ECM)、细胞与细胞的粘附。目前发现约有18种不同的α亚单
Integrin (integrin) is a cell adhesion molecule studied in various disciplines especially oncology in recent years. Its structure and function are complex and diverse, play an important role in tumorigenesis and progression, One of the directions to develop a target treatment. This article reviews the research status of integrin, and summarizes its research progress in bladder cancer. 1 integrin molecular structure integrin (integrin) is a large family of transmembrane proteins, family members are by α, β two subunits non-covalent bond formed by heterodimers, can mediate cells And extracellular matrix (ECM), cell and cell adhesion. There are currently about 18 different α subunits found