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目的 探讨新生儿中解脲脲原体 (ureaplasmaurealyticum ,UU)感染的临床相关因素。方法 随机选择 189例新生儿病房住院新生儿 ,应用培养和聚合酶链反应方法检测其咽部分泌物 ,同时用酶联免疫吸附试验检测新生儿血清UU IgM。详细记录临床资料。结果 住院新生儿咽部分泌物UU阳性率 2 5 9% ,其中早产儿 31 3% ,足月儿 2 4 1% (P >0 0 5 ) ;小于胎龄儿 2 9 7% ,适于胎龄儿2 5 0 % (P >0 0 5 )。新生儿肺炎患儿咽部分泌物UU阳性率为 38 5 % ,非感染性疾病患儿为 2 3 9%(P >0 0 5 )。胸部X线片异常者咽部分泌物阳性率为 31 8% ,正常者为 2 4 1% (P >0 0 5 )。血清UU IgM阳性率为 34 4% ,其中早产儿为 39 6 % ,足月儿为 32 6 % (P >0 0 5 ) ;小于胎龄儿为 48 6 % ,适于胎龄儿 30 9% (P <0 0 5 )。新生儿肺炎患儿血UU IgM阳性率为 5 3 8% ,非感染性疾病患儿为31 3% (P <0 0 2 5 ) ;X线胸片异常者UU IgM阳性率为 5 0 0 % ,正常者为 2 9 7% (P <0 0 2 5 )。 结论住院新生儿中小于胎龄儿UU感染率高于适于胎龄儿。UU感染与新生儿肺炎和胸部X线片异常者密切相关。
Objective To investigate the clinical factors related to ureaplasma urealyticum (UU) infection in neonates. Methods A total of 189 neonates admitted to neonatal wards were randomly selected and their pharyngeal secretions were detected by polymerase chain reaction and polymerase chain reaction. Serum UU IgM levels were measured by enzyme-linked immunosorbent assay (ELISA). Detailed record of clinical data. Results The positive rate of UU in hospitalized neonates was 25.9%, 31.3% of premature infants and 24.1% of full-term infants (P> 0.05), less than 29.7% of gestational age, suitable for fetal Aged 250% (P> 0.05). The positive rate of pharyngeal secretions was 38.5% in neonates with pneumonia and 23.3% in non-infectious diseases (P> 0.05). The positive rate of pharyngeal secretions was 31.8% in the cases of abnormal chest X-ray and 24.1% of the normal cases (P> 0.05). Serum UU IgM positive rate of 34 4%, 39.6% of preterm children, full-term children was 32 6% (P 0 05), less than gestational age 48 6%, suitable for gestational age children 30 9% (P <0 05). The positive rate of UU IgM in blood of neonates with pneumonia was 53.8% and that of non-infectious disease was 31.3% (P <0 025). The positive rate of UU IgM was 50% , And normal persons were 297% (P <0 0 2 5). Conclusion The prevalence of UU in infants younger than gestational age is higher than that in infants born to gestational age. UU infection and neonatal pneumonia and chest X-ray abnormalities are closely related.