巨球蛋白血症系一少见病,其特点为全身性起源于淋巴细胞的细胞过度增殖,产生大量巨蛋白之肿瘤性疾病。本病可分为原发性及继发性二种,原发性亦称Waldenstrom’s巨球蛋白血症。1944年为Waldenstrom’s首先发现而著称。继发于肿瘤、白血病、结缔组织病、慢性感染、肾病、肝硬变等;原发性者是一种原因不明,由于淋巴样浆细胞异常增生,并伴有结构纯一的免疫球蛋白增多而引起的恶性肿瘤性疾病。迄今文献报道较 Macroglobulinemia is a rare disease characterized by systemic hyperproliferation of lymphoid cells and the production of numerous megaloblastic neoplastic diseases. The disease can be divided into two primary and secondary, also known as Waldenstrom’s macroglobulinemia. 1944 Known for Waldenstrom’s first discovery. Secondary to tumor, leukemia, connective tissue disease, chronic infection, kidney disease, cirrhosis; primary cause is unknown, due to abnormal proliferation of lymphoid plasma cells, accompanied by an increase in the structure of pure immunoglobulin And cause the malignant tumor disease. So far reported in the literature