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目的探讨归芪地黄汤加减联合雷公藤多苷治疗系统性红斑狼疮(SLE)患者的疗效及其对生命质量的影响。方法选取2014年11月至2016年11月盘锦蓝天风湿病专科医院收治的SLE患者73例为研究对象,按照治疗方法分为对照组36例和研究组37例,对照组患者采用西药醋酸泼尼松治疗,研究组患者采用归芪地黄汤加减联合雷公藤多苷治疗。比较两组患者的疗效及不良反应发生率,采用简明健康状况调查量表(SF-36)评价两组患者治疗前后的生命质量。结果研究组患者的治疗总有效率为91.9%,高于对照组的72.2%,差异有统计学意义(P<0.05);治疗后,研究组患者的SF-36各维度评分均高于对照组,差异均有统计学意义(均P<0.05);研究组患者的不良反应发生率为5.4%,低于对照组的25.0%,差异有统计学意义(P<0.05)。结论归芪地黄汤加减联合雷公藤多苷治疗SLE效果显著,安全性高,可改善患者的生命质量。
Objective To investigate the curative effect of Guiqi Dihuang Decoction combined with tripterygium glycosides on patients with systemic lupus erythematosus (SLE) and its effect on quality of life. Methods Seventy-three patients with SLE admitted to Panjin Blue-sky Rheumatology Hospital from November 2014 to November 2016 were selected and divided into control group (36 cases) and study group (37 cases) according to the method of treatment. Patients in the control group were treated with western medicine prednisolone Song treatment, the study group patients with Guiqi Di Huang Decoction plus Tripterygium glycosides treatment. The curative effect and incidence of adverse reactions were compared between the two groups. The quality of life before and after treatment was evaluated by the Concise Health Survey Scale (SF-36). Results The total effective rate of study group was 91.9%, which was higher than that of the control group (72.2%), the difference was statistically significant (P <0.05). After treatment, SF-36 scores of study group were higher than those of control group (All P <0.05). The incidence of adverse reactions in the study group was 5.4%, which was lower than that in the control group (25.0%), the difference was statistically significant (P <0.05). Conclusion Guiqi Dihuang Decoction combined with tripterygium glycosides treatment of SLE significant effect, high safety, can improve the quality of life of patients.