作者用流行性出血热病毒Rn9株实验感染乳小白鼠(昆明种),发现病毒对组织器官的影响属于多脏器损伤,尤以肺肾较严重,表现为细胞变性、坏死;脑、脾病变较轻,表现为以淋巴细胞为主的细胞浸润。各脏器血管均受累。作者认为各脏器局部解剖结构,血管分布数量的差异是造成病变轻重的主要原因。透射电镜观察表明Rn9株病毒对各脏器细胞的损伤以线粒体和粗面内质网较为明显。 The author of the experimental infection with epidemic hemorrhagic fever virus Rn9 strains of white mice (Kunming species) and found that the impact of viruses on tissues and organs belonging to multiple organ injury, especially lung and kidney more serious, manifested as cell degeneration and necrosis; brain and spleen lesions Light, manifested as lymphocyte-predominant cell infiltration. Each organ blood vessels are involved. The authors believe that the local anatomical structure of various organs, the number of vascular variability is the main reason for the severity of the disease. Transmission electron microscopy showed that Rn9 strain had obvious mitochondria and rough endoplasmic reticulum damage to various organs.