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选取25名受试者(其中男11人,女14人)进行重复口服糖耐量试验(OGTT)和糖化血红蛋白(HbA1c)检测。根据OGTT结果分为正常糖耐量(NGT)、糖调节受损(IGR)和糖尿病(DM)3组,通过单因素方差分析。结果:NGT组两次FPG相关性(r=-0.348,P=0.0565)、2hPG相关性(r=0.413,P=0.490)、HbA1c相关性(r=-0.047,P=0.970);IGR组中,两次FPG相关性(r=0.728,P=0.026,P<0.05)、2hPG相关性(r=0.651,P=0.057)、HbA1c相关性(r=0.955,P=0.003,P<0.01);DM组中,两次FPG相关性(r=0.859,P=0.062)、2hPG相关性(r=-0.308,P=0.614)、HbA1c相关性(r=0.961,P=0.039,P<0.05)。结论:NGT组两次FPG2、hPG、HbA1c不存在有统计学意义的相关性;DM组两次HbA1c相关I,GR组两次FPG、HbA1c相关。口服葡萄糖耐量试验联合糖化血红蛋白测定为糖尿病筛查可靠方法之一。
Twenty-five subjects (11 males and 14 females) were enrolled in the OGTT and HbA1c tests. According to OGTT results, the patients were divided into three groups: normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes mellitus (DM). Results: There were significant differences in FPG correlation between NGT group (r = -0.348, P = 0.0565), 2hPG (r = 0.413, P = 0.490) and HbA1c (r = -0.047, (R = 0.728, P = 0.026, P <0.05), 2hPG correlation (r = 0.651, P = 0.057) and HbA1c correlation (r = 0.955, P = 0.003, P <0.01) DM group had two correlations of FPG (r = 0.859, P = 0.062), 2hPG correlation (r = -0.308, P = 0.614) and HbA1c correlation (r = 0.961, P = 0.039, P <0.05). CONCLUSION: There was no significant correlation between two FPG2, hPG and HbA1c in NGT group, and two FPG and HbA1c in HbA1c-related I and GR groups in DM group. Oral glucose tolerance test combined with glycosylated hemoglobin is one of the reliable methods of screening for diabetes.