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目的:研究顽痹清片的抗炎作用。方法:采用二甲苯致小鼠耳壳肿胀实验、小鼠毛细血管通透性实验、大鼠棉球肉芽肿实验、大鼠佐剂型关节炎实验,观察顽痹清片的抗炎作用。结果:顽痹清片高,中,低剂量各组,均可明显抑制二甲苯所致小鼠耳壳肿胀;高剂量组有明显抑制组胺所致小鼠腹腔毛细血管通透性增加的作用;高,中剂量组对肉芽组织增生及佐剂关节炎模型均有显著抑制作用。结论:顽痹清片有较好的抗炎作用。
Objective: To study the anti-inflammation effect of stubborn plague tablets. METHODS: The anti-inflammatory effects of the stubborn mice were investigated by xylene-induced mouse ear shell swelling experiment, mouse capillary permeability experiment, rat cotton granuloma experiment, and rat adjuvant arthritis experiment. RESULTS: The high, middle and low doses of Jiebiqing Tablets all significantly inhibited swelling of the ear shells in mice induced by xylene; and the high dose group significantly inhibited the increase of capillary permeability in the abdominal cavity of mice induced by histamine. The high and middle dose groups had significant inhibitory effects on granulation tissue proliferation and adjuvant arthritis models. Conclusion: The stubborn clear film has good anti-inflammatory effect.