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败血症是临床各科常见的、严重的而且是病死率较高的全身感染性疾病。近三十年来,败血症的病原菌菌种有很大变化。由于医学水平的不断提高,人口平均寿命延长,加之某些疾病的上升,一些新型手术的开展,抗生素、抗代谢药物的广泛应用,以及医院内大量耐药菌株的存在等诸多因素的影响,致使病原菌发生显著变化。以往少见的大肠杆菌、肺炎杆菌、绿脓杆菌、沙雷氏杆菌、变形杆菌等目前在败血症中已占重要位置。国内外报道,许多医院内发生的败血症主要由革兰氏阴性杆菌引起。上海第一医学院华山医院传染病教研组报告,630例败血症中革兰氏杆菌237例,占38.04%。其中大肠杆菌124例,产氧杆菌27例,产碱杆菌17
Sepsis is a common, serious, and most systemic infectious disease in clinical departments. Nearly three decades, sepsis pathogens have greatly changed. Due to the continuous improvement of the medical level, the prolongation of the average life expectancy of the population and the increase of certain diseases, the development of some new surgeries, the extensive application of antibiotics and antimetabolites, and the presence of a large number of drug-resistant strains in the hospital, Significant changes in pathogens. In the past rare E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, Proteus and so currently occupy an important position in sepsis. Domestic and international reports, sepsis occurring in many hospitals is mainly caused by Gram-negative bacilli. Huashan Hospital of Shanghai First Medical College Infectious Diseases Teaching and Research Group report, 630 cases of sepsis in 237 cases of gram-positive bacteria, accounting for 38.04%. Including 124 cases of Escherichia coli, Oxygen-producing bacteria in 27 cases, Alcaligenes 17