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目的分析应用干扰素治疗诱发甲状腺功能减退症的疗效。方法选择10例干扰素治疗诱发甲状腺功能减退症的病毒性肝炎患者作为观察组,选择同期15例未使用干扰素治疗的病毒性肝炎合并甲状腺功能减退症患者作为对照组。分析两组患者的肝功能等指标差异。结果两组患者肝功能指标、血清总三碘甲腺原氨酸(FT_3)、血清总甲状腺素(FT_4)比较,差异无统计学意义(P>0.05);对照组患者的促甲状腺素(TSH)水平高于观察组,差异有统计学意义(P<0.05);对两组患者进行8个月的随访,观察组5例患者需要长期应用左甲状腺素片治疗,对照组中全部患者使用左甲状腺素片治疗。结论使用干扰素治疗诱发产生甲状腺功能减退症后,要及时停药,以免对患者造成永久性且不可逆的损害,影响患者的正常生理功能。
Objective To analyze the therapeutic effect of interferon therapy on hypothyroidism. Methods Ten patients with viral hepatitis with hypothyroidism induced by interferon were selected as the observation group. Fifteen patients with concurrent viral hepatitis and hypothyroidism who were not treated with interferon were selected as the control group. Analysis of two groups of patients such as liver function differences. Results There was no significant difference in liver function indexes, serum total triiodothyronine (FT_3) and serum total thyroxine (FT_4) between the two groups (P> 0.05). The thyroid stimulating hormone ) Were significantly higher than those in the observation group (P <0.05). The two groups of patients were followed up for 8 months. In the observation group, 5 patients required long-term treatment with levothyroxine, and all patients in the control group Thyroid hormone tablets treatment. Conclusion Interferon therapy induced hypothyroidism induced, should be promptly discontinued, so as not to cause permanent and irreversible damage to patients, affecting the normal physiological function of patients.