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研究雌性老年前期大鼠性腺轴功能的变化．方法：应用阴道细胞形态学检查法和放射免疫测定法观察18月龄雌性SD大鼠动情周期和组织中性激素含量的变化．结果：18月龄雌性大鼠血清E2水平降低，LH和FSH含量升高；下丘脑和血浆GnRH水平上升，垂体GnRH含量减少．结论：18月龄雌性老年前期SD大鼠动情周期停止，下匠脑－垂体－卵巢轴功能明显衰退．
To study the changes of gonadal axis function in female presenile rats. Methods: Vaginal cell morphometry and radioimmunoassay were used to observe the changes of estrous cycle and sex hormone levels in 18-month-old female SD rats. Results: The E2 level of 18-month-old female rats decreased, while the contents of LH and FSH increased. The levels of GnRH in hypothalamus and plasma increased, and the content of GnRH in pituitary decreased. Conclusion: The estrous cycle of 18-month-old female pre-elderly SD rats stopped and the function of lower carp’s brain-pituitary-ovarian axis declined significantly.