RTK即受体酪氨酸激酶,是一类小分子跨膜蛋白质。其结构共同点是均有一个保守的激酶位点。RTK与其配体结合后,使激酶位点磷酸化,激活一系列下游信号途径。在结肠肿瘤中有多种RTK的异常表达,且与肿瘤的恶性程度相关。利用基因治疗或者RTK的抑制剂,可以延缓结肠肿瘤的发展。 RTK receptor tyrosine kinases, is a small class of transmembrane proteins. The structural common ground is that each has a conserved kinase site. When RTK binds to its ligand, it phosphorylates the kinase site and activates a series of downstream signaling pathways. Abnormal expression of multiple RTKs in colon tumors correlates with the malignancy of the tumor. The use of gene therapy or RTK inhibitors can delay the development of colon tumors.