胚胎同种移植的成败,在很大程度上取决于胚胎-胎盘间的作用。曾有人提出子宫可能是移植的免疫特权区,子宫局部的免疫调节机制有利于同种妊娠的成功。分泌期子宫内膜的前列腺素和孕酮呈高水平状态,它们能协同抑制T细胞增殖反应。此外还有几种免疫抑制因子参与了胚胎保护。 The success or failure of embryo allografts depends largely on the role of the embryo-placenta. It has been proposed that the uterus may be immune transplant privilege zone, uterine local immunomodulatory mechanisms conducive to the success of the same kind of pregnancy. Secretion of endometrial prostaglandins and progesterone showed a high level, they can synergistically inhibit T cell proliferation response. In addition there are several immunosuppressive factors involved in embryo protection.