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目的评价唑来膦酸治疗肺癌骨转移的临床效果。方法采用随机数字法抽选68例肺癌骨转移患者分为两组,甲组32例患者采用唑来膦酸治疗,乙组36例患者采用帕米膦酸二钠治疗,对比分析两组患者的治疗效果及不良反应。结果比较两组患者的治疗效果及不良反应情况,差异无统计学意义(P>0.05)。结论采用唑来膦酸治疗肺癌骨转移,其治疗效果与帕米膦酸二钠无明显差异,但前者使用方法更简单、易于患者接受。
Objective To evaluate the clinical efficacy of zoledronic acid in the treatment of bone metastases of lung cancer. Methods Sixty-eight patients with bone metastasis of lung cancer were randomly divided into two groups. 32 patients in group A were treated with zoledronic acid, 36 patients in group B were treated with pamidronate disodium, and the patients in both groups were compared Therapeutic effects and adverse reactions. Results The curative effect and adverse reaction of two groups of patients were compared, the difference was not statistically significant (P> 0.05). Conclusion Zoledronic acid treatment of bone metastases of lung cancer, the treatment effect and pamidronate disodium no significant difference, but the former method is more simple and easy for patients to accept.