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目的探讨X-rayrepaircross-complementinggroup3(XRCC3)T241M基因多态性与结直肠癌易感性的关系。方法通过计算机检索和手工检索,收集有关XRCC3Thr241Met基因多态性与结直肠癌易感性关系的文献,筛选出符合条件的文献,应用Meta分析软件对各项研究进行异质性检验,计算合并OR值及其95%可信区间,并进行敏感性分析和发表偏倚的评估。结果国内外共有10篇文献纳入本研究(结直肠癌患者:3003例;对照:4011例)。Meta分析结果显示:XRCC3Thr241Met基因多态性在研究对象中与结直肠癌无明显的关联性MTvs.TT:OR=0.942,95%CI=0.655～1.342,P=0.745;MM/TTvs.TT:OR=0.868,95%CI=0.572～1.318,P=0.536;MM/MTvs.TT:OR=0.948,95%CI=0.6491～1.383,P=0.738;MMvs.MT/TT:OR=0.907,95%CI=0.605～1.360,P=0.636,通过种族的分层分析,发现XRCC3Thr241Met基因多态性与结直肠癌易感性在亚洲人群和欧洲人群中无差异。结论 XRCC3Thr241Met基因多态性可能与结直肠癌间不存在明显易感性。
Objective To investigate the relationship between X-rayrepaircross-complementing group 3 (XRCC3) T241M gene polymorphism and susceptibility to colorectal cancer. Methods The literature about the relationship between XRCC3Thr241Met gene polymorphism and the susceptibility to colorectal cancer was collected by computer and manual search. The eligible documents were screened out. Meta analysis software was used to test the heterogeneity of each study. The combined OR And 95% confidence intervals, and conduct assessments of sensitivity and publication bias. Results A total of 10 articles were included in the study (colorectal cancer patients: 3003 cases; control: 4011 cases). Meta analysis showed that: XRCC3Thr241Met gene polymorphism in the study of colorectal cancer with no significant association MTvs.TT: OR = 0.942,95% CI = 0.655 ~ 1.342, P = 0.745;MM/TTvs.TT:OR = 0.868, 95% CI = 0.572-1.318, P = 0.536; MM / MTvs.TT: OR = 0.948,95% CI = 0.6491-1.383, P = 0.738; MMvs.MT/TT: OR = 0.907, 95% CI = 0.605 ~ 1.360, P = 0.636. According to the ethnic stratification analysis, it was found that the polymorphism of XRCC3Thr241Met and the susceptibility of colorectal cancer were not different between Asian and European populations. Conclusion The polymorphism of XRCC3Thr241Met may not be significantly associated with colorectal cancer.