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目的观察吉西他滨与顺铂联合化疗治疗晚期非小细胞肺癌的疗效和不良反应。方法吉西他滨1000mg/m2第1、8天静脉滴注并联合顺铂治疗晚期非小细胞肺癌50例,3周为1个治疗周期,2个周期后评价疗效和毒副作用。结果 50例均化疗2个周期以上,其中完全缓解(CR)1例,部分缓解(PR)20例,稳定(SD)19例,进展(PD)10例,缓解率(CR+PR)42%。结论吉西他滨联合顺铂治疗晚期非小细胞肺癌具有较好的疗效,且不良反应轻,患者可耐受。
Objective To observe the efficacy and side effects of gemcitabine combined with cisplatin in the treatment of advanced non-small cell lung cancer. Methods 50 cases of advanced non-small cell lung cancer were treated with gemcitabine 1000 mg / m2 on day 1 and day 8 by intravenous drip combined with cisplatin. One cycle was treated for 3 weeks, and the curative effect and side effects were evaluated after 2 cycles. Results All of the 50 cases were treated with more than 2 cycles of chemotherapy, including 1 complete remission (CR), 20 partial remission (PR), 19 stable (SD), 10 progressive (PD) . Conclusion Gemcitabine combined with cisplatin in the treatment of advanced non-small cell lung cancer has a good curative effect, and the side effects are mild and the patient can tolerate.