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测定了不同浓度肝素体外对肾病大鼠、肾病患儿及其各自的正常对照组外周血红细胞（ＲＢＣ）阴电荷的影响。结果表明，肾病组与其对照组一样，ＲＢＣ阴电荷量均随着肝素浓度的增高而增加。二者呈现明显正相关。但不同的是，肾病组与对照组相比，对低浓度肝素的敏感性下降，而对高浓度肝素则增强。由于实验结果证实，ＲＢＣ阴电荷量与ＫＰＴＴ及ＰＴ呈正相关，故肝素的上述作用也反映了其对凝血功能的影响。本文为观察肾病的高凝状态提供了新方法，并为肾病时使用低剂量肝素治疗的安全性提供了依据。
The effects of different concentrations of heparin on the negative charge of peripheral blood red blood cells (RBCs) in nephritic rats, nephrotic children and their respective normal controls were determined. The results showed that nephropathy group and its control group, RBC Yin charge increased with the increase of heparin concentration. The two showed a clear positive correlation. But the difference is that nephrosis group compared with the control group, the sensitivity of low concentration heparin decreased, while the high concentration of heparin is enhanced. As the experimental results confirmed that RBC negative charge and KPTT and PT was positively correlated, so the above effect of heparin also reflects its impact on coagulation. This article provides a new method for observing the hypercoagulable state of nephropathy and provides a basis for the safety of low-dose heparin therapy for nephropathy.