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目的 观察新型免疫抑制剂霉酚酸酯 (MMF)对系统性红斑狼疮 (SLE)免疫功能的影响。方法 应用ELISA法、间接免疫荧光法和流式细胞术观察MMF、环磷酰胺 (CTX)治疗前后SLE患者血清IL 6、IL 8、TNF α、sIL 2R、ANA、A dsDNA及淋巴细胞亚群的变化以及MMF、CTX对造血系统、肝脏、肾脏功能的影响。结果 SLE患者经MMF治疗 3个月后血清IL 6、IL 8、TNF α、sIL 2R、ANA、A dsDNA水平显著下降 ,CD3+ 、CD4+ 、CD4+ CD45RA+ 细胞显著增高 ,CD8+ 、CD4+CD45RO+ 、CD8+ CD45RA+ 、CD8+ CD45RO+ 细胞显著减少。对造血系统、肝脏、肾脏功能无明显损害。结论 MMF可选择性地抑制T、B淋巴细胞 ,是一种治疗SLE毒副作用较少的新型免疫抑制剂。
Objective To observe the effect of a novel immunosuppressive drug, mycophenolate mofetil (MMF), on the immune function of systemic lupus erythematosus (SLE). Methods Serum IL 6, IL 8, TNFα, sIL 2R, ANA, A dsDNA and lymphocyte subsets of patients with SLE before and after treatment with MMF and CTX were detected by ELISA, indirect immunofluorescence and flow cytometry Changes and MMF, CTX on hematopoietic system, liver, kidney function. Results Serum IL 6, IL 8, TNFα, sIL 2R, ANA and A dsDNA levels were significantly decreased in patients with SLE after 3 months of MMF treatment. The levels of CD8 +, CD4 + CD45RO +, CD8 + CD45RA + CD8 + CD45RO + cells were significantly reduced. No significant damage to the hematopoietic system, liver, kidney function. Conclusion MMF can selectively inhibit T and B lymphocytes and is a novel immunosuppressant with less side effects of SLE.