论文部分内容阅读
目的探讨沙漠干热环境下不同温度对创伤失血性休克猪生存时间的影响,为进一步的研究提供理论依据。方法选取雄性的长白仔猪30头(25—35 kg),随机分为常温实验组(环境温度25℃±1℃,湿度35%±5%,n=10),干热环境Ⅰ组(环境温度40.5℃±0.5℃,湿度10%±2%,n=10头),干热环境Ⅱ组(环境温度41.5℃±0.5℃,湿度10%±2%,n=10头)。将实验动物置于人工实验舱内,按实验设计设置相应的环境参数,分别在各自环境暴露3 h,建创伤失血性休克模型,观察生命体征及死亡时间。结果 1.常温组创伤失血性休克后体温较长时间稳定在一定水平,稳定期后呈进行性下降;而干热Ⅰ组休克后缓慢上升,两相邻时间点温度无显著差异;干热Ⅱ组模型成功后体温很快升至42℃,一直呈快速上升趋势,直至动物死亡,相邻两时间点体温差异显著。2.常温组模型成功后三组的平均存活时间分别是(567±16.9)min、(178±3.6)min、(61±2.8)min,三组平均生存时间差异显著。结论 1.沙漠干热环境创伤失血性休克存活时间明显短于常温环境,提示沙漠干热环境可加速创伤失血性休克动物死亡;2.而沙漠干热环境Ⅱ组存活时间更短,提示在沙漠干热环境下,环境每升高1℃,可明显缩短创伤失血性休克猪的生存时间。3.体温升高的速度与死亡速度呈正相关,温度升高越快死亡时间快,生存时间越短,提示沙漠干热环境创伤失血性休克救治过程中有效地控制体温可能具有重要的临床意义。
Objective To investigate the effects of different temperatures on the survival time of pigs with traumatic hemorrhagic shock in the dry and hot desert environment, and provide a theoretical basis for further research. Methods Thirty male Changbai piglets (25-35 kg) were randomly divided into normal temperature experimental group (ambient temperature 25 ℃ ± 1 ℃, humidity 35% ± 5%, n = 10), dry heat environment group Ⅰ 40.5 ℃ ± 0.5 ℃, humidity 10% ± 2%, n = 10), dry heat environment Ⅱ group (ambient temperature 41.5 ℃ ± 0.5 ℃, humidity 10% ± 2%, n = 10). The experimental animals were placed in the artificial experiment chamber, and the corresponding environmental parameters were set according to the experimental design. The traumatic hemorrhagic shock model was established and the vital signs and the time of death were observed 3 hours after exposure respectively. The results showed that body temperature in traumatic hemorrhagic shock in normal temperature group was stable at a certain level for a long time, and then decreased in a steady state. However, dry heat group Ⅰ increased slowly after shock and had no significant difference between two adjacent time points. After the success of the model group, the body temperature rapidly rose to 42 ° C, which showed a rapid upward trend until the animal died, with significant differences in body temperature between two adjacent time points. The mean survival time of the three groups were (567 ± 16.9) min, (178 ± 3.6) min and (61 ± 2.8) min after the model group was successfully treated, respectively. The average survival time of the three groups was significantly different. The survival time of traumatic hemorrhagic shock in dry and hot environment in desert was significantly shorter than that in normal temperature, suggesting that dry and hot environment in desert accelerated the death of traumatic hemorrhagic shock animals.2. The survival time in dry and warm environment II was shorter, which suggested that in desert Dry and hot environment, the environment increased by 1 ℃, can significantly reduce the survival time of traumatic hemorrhagic shock pigs. 3. The rate of increase of body temperature is positively correlated with the rate of death. The faster the temperature rises, the faster the death is and the shorter the survival time is. It suggests that it may have important clinical significance to effectively control body temperature in the treatment of traumatic hemorrhagic shock in desert dry and hot environment.