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应用国产试剂盒对Ⅲ型前胶原肽(PⅡP)、N型胶原肽(N—C)、板层素(LN)和透明质酸(HA)4项血清学标志物作联合检测,比较其在慢性迁延性肝炎(CPH),慢性活动性肝炎(CAH)和肝炎后肝硬化(LC)血清中的水平。结果,CAH患者分别为16.29±3.58U/ml,216.49±100.86ng/ml,196.87±88.45ng/ml,147.55±36.85ng/ml,LC患者分别为21.04±4.74U/ml,385.8±95.76ng/ml,769.29±652.28ng/ml,182.56±44.39ng/ml。与正常人相比均有显著性差异,P值<0.05,LC高于CAH。而CPH除HA外与正常人相比无显著性差异,P值>0.05。与国内文献报道相似。4项指标与ALT增高无相关性,与血清蛋白电泳中γ球蛋白增高有显著相关性。联合检测有功于LC的诊断及疗效观察。
Four national serological markers of PⅡP, N-C, LN and HA were detected by using a domestic kit. Chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and hepatitis cirrhosis (LC) serum. The results showed that the CAH patients were 16.29 ± 3.58U / ml, 216.49 ± 100.86ng / ml, 196.87 ± 88.45ng / ml and 147.55 ± 36.85ng / ml respectively. The LC patients were 21.04 ± 4.74U / ml and 385.8 ± 95.76ng / ml, 769.29 ± 652.28 ng / ml, 182.56 ± 44.39 ng / ml. Compared with normal people, there are significant differences, P value <0.05, LC higher than CAH. However, there was no significant difference between CPH and normal subjects except HA (P> 0.05). Similar with the domestic literature. There was no correlation between the four indexes and the increase of ALT, which was significantly correlated with the increase of γ-globulin in serum protein electrophoresis. Joint detection of active in the diagnosis of LC and efficacy.