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目的:探讨孕妇孕中期血清标志物筛查与胎儿唐氏综合征检出的关系。方法:应用Beckman Coulter公司Access全自动分析仪对2458例孕中期孕妇血清进行甲胎蛋白(AFP)、总β绒毛膜促性腺激素(T-βHCG)及游离雌三醇(uE3)3项指标检测,并用专用软件分析,预测胎儿患DS的风险,风险率>1:385定为筛查阳性,再作羊水检查以确认。结果:2458例孕妇中筛查为阳性者62例(2.52%),通过自愿作羊水染色体检查,检出唐氏综合征胎儿3例,遗漏1例,检出率为(1.22‰)。结论:孕中期孕妇血清三联筛查胎儿唐氏综合征是行之有效的方法,可以作为产前筛查的常规手段。
Objective: To investigate the relationship between the screening of serum markers in pregnant women in the second trimester and detection of Down’s syndrome. Methods: A total of 2458 pregnant women of the second trimester were tested for AFP, T-βHCG and uE3 using Beckman Coulter Access Auto Analyzer. , And with special software analysis to predict the risk of fetal DS, the risk of> 1: 385 as positive screening, then check for confirmation of amniotic fluid. Results: Among 2458 pregnant women, 62 cases were positive (2.52%). According to the chromosomal test of amniotic fluid voluntarily, 3 cases of Down syndrome were detected and 1 case was missed. The detection rate was (1.22 ‰). Conclusion: Trimester screening pregnant women with Down’s syndrome is an effective method for detecting prenatal screening, which can be used as a routine measure of prenatal screening.