子痫前期是一种严重的妊娠并发症,其发病的二阶段学说是该病重要的病理生理学基础。滋养细胞的发育、分化及细胞间的融合作用,是其发挥侵袭功能的前提。众多分子可影响滋养细胞的功能,大量证据表明,表观遗传学与子痫前期的发病存在联系,但其在子痫前期发病中的作用仍需进一步研究。本文着重讨论表观遗传学中组蛋白修饰对滋养细胞功能的影响,为研究子痫前期的发生发展提供新的方向。 Preeclampsia is a serious pregnancy complications, the incidence of two-phase theory is an important pathophysiology of the disease basis. Trophoblast development, differentiation and cell-cell fusion are the prerequisites for its invasive function. Numerous molecules can affect the function of trophoblasts. There is a lot of evidence that there is a relationship between epigenetics and the pathogenesis of preeclampsia. However, its role in the pathogenesis of preeclampsia needs further study. This article focuses on the epigenetics of histone modification on trophoblast function in order to study the occurrence and development of preeclampsia provide a new direction.