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早期的一些报道认为几乎所有AITP病人都可发现PAIgG(血小板相关IgG)。现今的看法则是10—30％的患者不能查出抗血小板活性。大多数作者集中检测PAIgG而很少注意PAIgM(血小板相关IgM)型自身抗体。本文研究145名ATIP病人证实相当一部分患者除PAIgG升高外,还有PAIgM的增加。作者用酶联检测系统对35名正常人和145名病人的血小板抽样物分别进行试验,正常人的PAIgG为6.0ng/10_-~6pl,(2.0—10ng),PAIgM为1.17ng/10_-~6pl(0.01—2.45ng)、(M±2SD)。145名病人的PAIgG值1.6-300ng/10_-~6plPAI~M值0.2—130
Some earlier reports suggested that PAIgG (platelet-associated IgG) was found in almost all AITP patients. The current view is that 10-30% of patients can not detect anti-platelet activity. Most authors focus on PAIgG and pay little attention to PAIgM (platelet-associated IgM) autoantibodies. This study of 145 ATIP patients confirmed that a significant proportion of patients in addition to PAIgG increased, there PAIgM increase. The authors tested the platelet samples of 35 normal subjects and 145 patients with enzyme linked detection system. The normal subjects had a PAIgG of 6.0ng / 10_- ~ 6pl (2.0-10ng) and PAIgM of 1.17ng / 10_ ~ 6pl (0.01-2.45ng), (M ± 2SD). 145 patients PAIgG value of 1.6-300ng / 10_ - ~ 6plPAI ~ M value of 0.2-130