论文部分内容阅读
目的 :研究硫糖铝和盐酸雷尼替丁合用对 4种大鼠胃溃疡模型的影响。方法 :用水浸应激型、乙酸灼烧型、乙醇致胃粘膜损伤型、幽门结扎型溃疡模型方法试验。结果 :硫糖铝和盐酸雷尼替丁单用或不同剂量合用对水浸应激型、乙酸灼烧型、乙醇致胃粘膜损伤型均有预防或治疗作用。两药单用对幽门结扎型溃疡无显著治疗作用 ,联合应用对乙酸灼烧型和幽门结扎型溃疡模型的预防和治疗效果尤为突出 ,其预防或治疗作用比两药各自单用效果好。两药合用对水浸应激型溃疡模型的保护作用与盐酸雷尼替丁单用相当 ,对乙醇致胃粘膜损伤模型的保护作用与硫糖铝单用相当。
AIM: To investigate the effects of sucralfate and ranitidine hydrochloride on four models of gastric ulcer in rats. Methods: The water immersion type, acetic acid burning type, ethanol induced gastric mucosal injury, pylorus ligation ulcer model test. Results: Combination of sucralfate and ranitidine hydrochloride alone or in combination with different doses could prevent or treat gastric mucosa injury induced by water immersion, acetic acid burning and ethanol. The two drugs alone had no significant effect on the pyloric ligation ulcer, the combined application of acetic acid burning and pylorus ligation ulcer model prevention and treatment is particularly prominent, its prevention or treatment effect than the two drugs alone with good results. The combination of the two drugs on flooding stress ulcer model and ranitidine hydrochloride alone was equivalent to ethanol induced gastric mucosal injury model and sucralfate alone comparable.