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[目的]探讨肝X受体α(LXRα)在胃癌组织中表达的临床意义。[方法]收集2011年5月至2014年5月在上海市第五人民医院手术的胃癌组织及癌旁正常组织各65例,利用免疫组化和荧光定量PCR方法检测各组织中LXRα的表达,分析LXRα表达与胃癌临床病理特征的关系。[结果]LXRα蛋白在胃癌组织中表达高于癌旁正常组织(P=0.000);LXRα在超过5cm的胃癌组织中表达高于5cm以下的肿瘤(χ2=6.744,P=0.011),有淋巴结转移高于无淋巴结转移(χ2=28.765,P=0.000),有远处转移高于无远处转移(χ2=5.647,P=0.024),T分期越高表达越高(χ2=13.965,P=0.003);LXRα表达与年龄(χ2=0.018,P=1.000)、性别(χ2=0.492,P=0.728)、肿瘤部位(χ2=1.400,P=0.266)及病理分型(χ2=0.376,P=0.945)无明显相关。[结论 ]LXRα蛋白在胃癌组织中表达更高,与胃癌大小、淋巴结转移、远处转移和T分期相关;推测LXRα参与调控胃癌生长转移。
[Objective] To investigate the clinical significance of liver X receptor α (LXRα) expression in gastric cancer. [Methods] Totally 65 gastric cancer tissues and adjacent normal tissues were collected from May 2011 to May 2014 in Shanghai Fifth People’s Hospital. The expression of LXRα in each tissue was detected by immunohistochemistry and fluorescent quantitative PCR. The relationship between LXRα expression and clinicopathological features of gastric cancer was analyzed. [Results] The expression of LXRα protein in gastric cancer was higher than that in adjacent normal tissues (P = 0.000). The expression of LXRα in gastric cancer over 5cm was higher than that in tumors below 5cm (χ2 = 6.744, P = 0.011) Higher than without lymph node metastasis (χ2 = 28.765, P = 0.000), higher distant metastasis than distant metastasis (χ2 = 5.647, P = 0.024) (Χ2 = 0.492, P = 0.728), tumor location (χ2 = 1.400, P = 0.266) and pathological type (χ2 = 0.376, P = 0.945) ) No significant correlation. [Conclusion] The expression of LXRα protein is higher in gastric cancer tissues, which is related to the size, lymph node metastasis, distant metastasis and T stage of gastric cancer. It is speculated that LXRα is involved in the regulation of gastric cancer metastasis.