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目的探讨骨科手术中抗菌药物防治感染的疗效。方法 120例接受骨科手术治疗的患者,随机分为观察组与参考组,每组60例。观察组患者术前0.5~1.0 h内、术后12 h均静脉滴注足量抗菌药物,参考组患者术后静脉滴注抗菌药物持续7 d。观察两组患者术后感染率、愈合率及术后住院时间。结果观察组术后感染发生率1.7%低于参考组13.3%,差异具有统计学意义(P<0.05)。观察组术后甲级愈合率50.0%高于参考组31.7%,差异具有统计学意义(P<0.05)。观察组平均术后住院时间(15.77±1.56)d短于参考组(19.65±2.08)d,差异有统计学意义(P<0.05)。结论骨科手术中把握合适的抗菌药物使用时机能够降低术后感染的发生,促进患者术后康复。
Objective To investigate the efficacy of antibacterials in the prevention and treatment of infections in orthopedic surgery. Methods A total of 120 patients undergoing orthopedic surgery were randomly divided into observation group and reference group, 60 cases in each group. Patients in the observation group received intravenous infusion of adequate antibiotics within 0.5-1.0 h before operation and 12 h after operation, and patients in the reference group received intravenous antibiotics for 7 days after operation. Postoperative infection rate, healing rate and postoperative hospital stay were observed in two groups. Results The incidence of postoperative infection in the observation group was 1.7% lower than that in the reference group (13.3%), the difference was statistically significant (P <0.05). The postoperative grade A healing rate in observation group was 50.0% higher than that in reference group (31.7%), the difference was statistically significant (P <0.05). The average postoperative hospital stay (15.77 ± 1.56) d in observation group was shorter than that in reference group (19.65 ± 2.08) d, the difference was statistically significant (P <0.05). Conclusion The appropriate timing of antimicrobial use in orthopedic surgery can reduce the incidence of postoperative infection and promote postoperative recovery.