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组织损伤和感染造成了宿主的代谢和免疫内环境的显著变化。越来越清楚这些变化大多起因于单核吞噬细胞所产生的内源性介导物的一种复杂的连锁反应。其中较为重要的是一组被称为细胞因子的蛋白质,在介导宿主对组织损伤和感染的反应中起到了一种整合的作用。虽然细胞因子是一组各不相同的蛋白质,但它们都具有许多共同的特性,故大致可被分为三类:(1)单核细胞因子(如肿瘤坏死因子-a:TNF-a,白介素-1:IL-1),主要由单核吞噬细胞产生;(2)淋巴因子
Tissue damage and infection cause significant changes in host metabolism and immune homeostasis. It is increasingly clear that these changes are mostly due to a complex chain reaction of endogenous mediators produced by mononuclear phagocytes. More importantly, a group of proteins called cytokines play an integral role in mediating host response to tissue damage and infection. Although cytokines are a diverse set of proteins that all share many common properties, they are broadly classified into three categories: (1) monocytes (such as tumor necrosis factor-a: TNF-a, interleukin -1: IL-1), mainly produced by mononuclear phagocytes; (2) lymphokines