阿司匹林对宫颈癌裸鼠移植瘤组织中Bax及VEGF表达的影响

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目的探讨阿司匹林对宫颈癌裸鼠移植瘤组织中Bax及血管内皮生长因子(VEGF)表达的影响。方法健康雌性裸鼠40只,背部皮下接种He La细胞后随机分为4组,各10只。阿司匹林组给予阿司匹林50 mg/(kg·d);顺铂组给予顺铂15 mg/kg;联合用药组同时给予阿司匹林和顺铂;对照组给予同等剂量的乙醇和生理盐水。观察各组移植瘤生长情况,计算抑瘤率;免疫组化法检测各组Bax及VEGF表达量。结果与对照组相比,其余3组肿瘤体积、肿瘤质量显著降低(P〈0.05或P〈0.01),阿司匹林组、顺铂组、联合
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