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肝复康是由人参茎叶皂甙和柴胡皂甙组成的复力制剂。苏联临床认为人参对于急性肝炎转为慢性肝炎有预防和治疗作用。近年药理学研究证明,人参可提高肝脏解毒和排泄机能,对肝脏的RNA和蛋白质合成均有刺激作用。Hahn和王本祥等分别报告人参皂甙对四氯化碳和硫代乙酰胺引起的家兔和小鼠肝脏损伤具有明显的保护作用。 柴胡是治疗肝病复方大(小)柴胡汤的“君”药。现代药理学研究证明,柴胡皂甙具有抗炎和抑制四氯化碳等化学物质引起肝损伤作用。人参皂甙和柴胡皂甙虽均具有保肝作用,但两者的作用原理并不完全相同。我们设想若将它们组成复方,可能使两者的保肝作用互相协同,使治疗肝炎的效果增强。现将肝复康对多种实验性肝损伤影响的研究结果报告如下。
Liver rehabilitation is composed of ginseng stem saponin and saikosaponin. The Soviet Union believes that ginseng has a preventive and therapeutic effect on the conversion of acute hepatitis to chronic hepatitis. In recent years, pharmacological studies have shown that ginseng can improve liver detoxification and excretory function, stimulating both liver RNA and protein synthesis. Hahn and Wang Benxiang separately reported that ginsenosides have significant protective effects on liver injury induced by carbon tetrachloride and thioacetamide in rabbits and mice. Bupleurum is a “jun” drug for the treatment of liver disease compound large (small) Bupleurum decoction. Modern pharmacological studies have shown that saikosaponin has anti-inflammatory and carbon tetrachloride and other chemical substances causing liver damage. Although ginsenosides and saikosaponin have hepatoprotective effects, the principle of action of the two is not exactly the same. We envisage that if they are combined into one compound, the liver protection of the two may be synergistic and the effect of treating hepatitis will be enhanced. The results of research on the effects of Ganfukang on various experimental liver injuries are reported below.