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目的观察α-2b干扰素联合利巴韦林治疗成人麻疹的临床疗效。方法选择63例确诊麻疹患者,随机分为两组,均依据病情予对症、抗感染治疗,在此基础上,治疗组肌内注射α-2b干扰素100万单位,每日1次肌内注射,联合利巴韦林(利巴韦林)0.4/d,溶于10%葡萄糖液250ml静脉滴注,每天1次。对照组予静脉滴注利巴韦林(利巴韦林),治法同上,同时给于vitC、vitB与支持对症治疗。观察治疗后对体温变化、皮疹出齐及皮疹消退时间的影响。结果治疗组在体温恢复正常、皮疹出齐、皮疹消退及减少并发症方面均优于对照组,两组比较有统计学意义(P<0.01)。结论α-2b干扰素联合利巴韦林治疗成人麻疹能明显缩短病程、临床疗效满意,未见不良反应。
Objective To observe the clinical efficacy of α-2b interferon combined with ribavirin in the treatment of adult measles. Methods Sixty-three measles patients were selected and divided into two groups at random. All patients were treated with symptomatic and anti-infective treatment according to their condition. On the basis of this, intramuscular 1 million interferon α-2b was injected into the treatment group and intramuscularly , Combined with ribavirin (ribavirin) 0.4 / d, dissolved in 250ml of 10% glucose solution intravenously, once daily. The control group was given intravenous ribavirin (ribavirin), the same as above, while giving vitC, vitB and support symptomatic treatment. After treatment, the changes of body temperature, skin rashes and rash subsidence time were observed. Results The treatment group was better than the control group in returning normal temperature, rash, rash subsidence and complications. There was significant difference between the two groups (P <0.01). Conclusion The treatment of adult measles with interferon alfa-2b combined with ribavirin can shorten the course of the disease and the clinical efficacy is satisfactory with no adverse reactions.