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目的：通过观察低分子量肝素（ＬＭＷＨ）对小鼠凝血时间及大鼠静脉血栓形成的影响，对其主要药效学进行了研究，并与国外同类产品Ｃｌｉｖａｒｉｎ及普通肝素进行了比较。方法：玻片法体外测定小鼠全血凝血时间及大鼠体内静脉血栓形成法。结果：ＬＭＷＨｓｃ，４５０，１５０及５０ｕ／ｋｇ可明显延长小鼠全血凝血时间；ｓｃ，１００，３０ｕ／ｋｇ可明显降低大鼠静脉血栓重量。与相同剂量Ｃｌｉｖａｒｉｎ比较，二者药效相当；与普通肝素比较，ＬＭＷＨ有效剂量明显低于普通肝素。结论：ＬＭＷＨ具有生物利用度高、抗栓作用强及对凝血系统影响小的特性。
OBJECTIVE: To observe the effect of low molecular weight heparin (LMWH) on clotting time and venous thrombosis in rats. The main pharmacodynamics of LMWH were compared with Clivarin and unfractionated heparin. Methods: The whole blood clotting time in mice was determined by slide method and venous thrombosis in rats. Results: LMWHsc, 450,150 and 50u / kg could significantly prolong the whole blood clotting time of mice; sc, 100,30u / kg could significantly reduce the weight of venous thrombus in rats. Compared with the same dose of Clivarin, the efficacy of the two was comparable; compared with unfractionated heparin, the effective dose of LMWH was significantly lower than that of unfractionated heparin. Conclusion: LMWH has the characteristics of high bioavailability, strong antithrombotic effect and little influence on the coagulation system.