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目的探讨组织缺氧诱导因子-1α(HIF-1α)及血管内皮生长因子(VEGF)在鼻息肉组织中的表达及相关性,探讨局部应用糖皮质激素类药物对鼻息肉的作用机制。方法采用免疫组化SP法检测鼻息肉组织在应用丙酸氟替卡松鼻喷剂治疗前、后及下鼻甲HIF-1α及VEGF的表达变化。结果鼻息肉组织中HIF-1α和VEGF的表达水平明显高于下鼻甲组织(P均<0.01);激素治疗后HIF-1α、VEGF表达下降(P<0.05)。鼻息肉的发病与组织中HIF-1α、VEGF的表达呈明显正相关(r=0.627,P<0.05)。结论局部应用糖皮质激素可降低HIF-1α、VEGF的表达,有效治疗鼻息肉。
Objective To investigate the expression and correlation of tissue hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in nasal polyps and to explore the mechanism of local application of glucocorticoid on nasal polyps. Methods Immunohistochemical SP method was used to detect the expression of HIF-1α and VEGF in nasal polyps before, after and after treatment with fluticasone propionate nasal spray. Results The expression of HIF-1α and VEGF in nasal polyps was significantly higher than that in inferior turbinate tissues (all P <0.01). The expression of HIF-1α and VEGF decreased after Hormone treatment (P <0.05). The incidence of nasal polyps was positively correlated with the expression of HIF-1α and VEGF (r = 0.627, P <0.05). Conclusion Topical application of glucocorticoid can reduce the expression of HIF-1α and VEGF, and effectively treat nasal polyps.