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目的通过对诊断为弥漫性毒性甲状腺肿(Graves病)经过131I治疗患者的睾酮、雌二醇的水平检测,进一步探讨131I治疗后对患者的性激素水平的影响。方法对我院收治的初诊为甲亢Graves病、并采用131I治疗的81例患者为研究对象。分别于服用131I的治疗前、治疗后15d和6个月,进行睾酮、雌二醇水平的测定,以此判断其对性激素的影响。结果男性患者治疗后15天的睾酮水平与治疗前相比,则有明显的差异(q=6.837,P<0.01);治疗后6个月与治疗前相比(q=1.837,P>0.05),表明差异无统计学意义;男性患者的雌二醇水平的变化也与前者相同。女性患者治疗后15、6个月后睾酮的水平与治疗前相比(F=2.342,P>0.05),差异无统计学意义,女性患者的雌二醇治疗后15、6个月后的水平与治疗前相比(F=2.524,P>0.05),差异无统计学意义,女性睾酮及雌二醇水平治疗前后整体变化不明显。结论 131I治疗Graves病时,男性性激素在短期内可能有一定的影响,而远期可恢复;而在女性则治疗对其影响较小。
Objective To investigate the effect of 131I treatment on sex hormones in patients with 131I-treated patients diagnosed with diffuse toxic goiter (graves disease). Methods admitted to our hospital for the first diagnosis of hyperthyroidism Graves disease, and the use of 131I treatment of 81 patients for the study. Before taking 131I treatment, 15d and 6 months after treatment, testosterone and estradiol levels were measured to determine their effects on sex hormones. Results Compared with those before treatment, the level of testosterone in male patients after 15 days of treatment was significantly different (q = 6.837, P <0.01). Compared with those before treatment (q = 1.837, P> 0.05) , Indicating that the difference was not statistically significant; male patients with changes in estradiol levels with the former. The level of testosterone in female patients after 15 and 6 months of treatment was not significantly different from that before treatment (F = 2.342, P> 0.05), and the level of testosterone in female patients 15 and 6 months after estradiol treatment Compared with that before treatment (F = 2.524, P> 0.05), the difference was not statistically significant. There was no obvious change in the level of testosterone and estradiol in female before and after treatment. Conclusion 131I treatment of Graves disease, male sex hormones in the short term may have some effect, but long-term recovery; while the treatment of women is less affected.