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８４例经胃镜证实的Ｈｐ阳性十二指肠溃疡患者，随机分成二组分别接受兰索拉唑或奥美拉唑加用阿莫西林的根除Ｈｐ治疗。服法ＬＡＮ３０ｍｇ或ＯＭＥ２０ｍｇ，每日２次（早晚服），均加ＡＭＯ０．５ｇ，每日４次（３餐后及睡前），连服１０天为一疗程。以１４Ｃ－尿素呼吸试验判断根除与否。结果二组根除率相近，分别为８０％（３２／４０）、７８％（２９／３７）。二组副反应发生率均低（ＬＡＮ组１例轻度腹泻，１例皮疹；ＯＭＥ组１例轻度腹泻）。结果显示质子泵抑制剂加ＡＭＯ二联疗法具有症状缓解迅速、Ｈｐ根除率高、副反应少、病人依从性好等优点，是一种较理想的根除Ｈｐ治疗方案。
Eighty-four patients with Hp-positive duodenal ulcer confirmed by gastroscopy were randomly divided into two groups, receiving lansoprazole or omeprazole plus amoxicillin for eradication of Hp. Method LAN30mg or OME20mg, 2 times a day (morning and evening service), are added AMO0.5g, 4 times a day (3 meals and before going to bed), and even served 10 days for a course of treatment. To 14C-urea breath test to determine whether the eradication or not. Results The two groups had similar eradication rates of 80% (32/40) and 78% (29/37), respectively. The incidence of side effects in both groups was low (1 case of mild diarrhea and 1 case of rash in LAN group; 1 case of mild diarrhea in OME group). The results showed that the proton pump inhibitor combined with AMO dual therapy has the advantages of rapid remission, high Hp eradication rate, fewer side effects and good patient compliance. It is an ideal therapy for Hp eradication.