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青少年鼻咽血管纤维瘤(JNA)虽属良性,但局部破坏性强,手术摘除不彻底易复发,肿瘤侵入颅内可危及生命。本文报告了5例患者化疗的经验,这些患者的瘤体已侵犯颅内或眼眶或两者都累及。作者认为化疗对于某些经过选择的病例是有价值的。 5例患者的瘤体均是颅外摘除术后复发者,4例在复发前已行放疗。复发的肿瘤向颅内、外发展,接近或累及蝶窦周围的生命结构及其邻近的血管和神经。化疗的方案有两种,全身用药。
Although juvenile nasopharyngeal angiofibroma (JNA) is benign, it is locally destructive and surgical removal is not always recurable. Invasion of the tumor into the brain may endanger life. This article reports the experience of chemotherapy in 5 patients whose tumors have been invaded by intracranial or orbital or both. The authors believe that chemotherapy is valuable for certain selected cases. The tumors in 5 patients were all recurred after extracranial enucleation, and 4 patients had undergone radiotherapy before relapse. The recurrent tumor develops intracranially and externally, approaching or involving the vital structures around the sphenoid sinus and its adjacent blood vessels and nerves. There are two options for chemotherapy, systemic medication.