目的:比较不同粒径龙血竭粉的一般物理性质及体外溶出度。方法:对不同粒径龙血竭粉的外观性状、流动性、浸出物、水分、吸湿性及体外溶出度等进行比较研究。结果:超微粉碎后,龙血竭粉的一般物理性质及体外溶出度均发生一定改变。随粒径的减小,龙血竭粉体逐渐出现团聚现象,颜色变浅,粉末细腻,颗粒感消失。流动性变差,浸出物含量(冷浸法、热浸法)增加,含水量增加,吸湿性变强,体外溶出度提高。结论:与80目细粉比较,龙血竭超微粉的一般物理性质和体外溶出度均发生一定变化,为龙血竭的超微粉入药提供实验依据。 Objective: To compare the general physical properties and in vitro dissolution of dragon’s blood powder of different particle size. Methods: The appearance, flowability, extract, moisture, hygroscopicity and in vitro dissolution of DRG powder with different particle size were compared. Results: After ultrafine grinding, the general physical properties of DRX powder and in vitro dissolution of certain changes have taken place. With the decrease of the particle size, the dragon’s blood dried powder gradually appears agglomeration phenomenon, the color becomes lighter, the powder is delicate and the granular feeling disappears. Liquidity deteriorated, extract content (cold soak method, hot-dip method) increases, water content increases, hygroscopicity becomes stronger, in vitro dissolution increased. CONCLUSION: Compared with 80 mesh fines, the general physical properties and in vitro dissolution of DRX ultrafine powder have some changes, which provide the experimental basis for the DRG drug.