论文部分内容阅读
合成了2-苯基-4-硒唑甲酸配体(HL)和相应的6个过渡金属配合物[ML2(H2O)2](M=Co,Ni,Cu,Cd)1～4,[ZnL2](5),[CuL2(py)2](6).用元素分析、红外光谱、热重分析等表征手段确定了配合物的组成;用单晶X射线衍射测定了配合物3和6的结构;用溴化乙锭荧光探针初步研究了它们与DNA作用的强度和模式;考察了配体和配合物对大肠埃氏杆菌(E.coliJM109)、大肠杆菌(E.coli,DH5α)、表皮葡萄球菌(S.epidermidis)、金黄色葡萄球菌(S.aureus)、鲍曼不动杆菌(baumanii)、草绿色链球菌(S.viridans)6种细菌的抗菌活性及对正常细胞293T和肿瘤细胞RAW264.72的体外增殖抑制作用.
(HL) and the corresponding six transition metal complexes [ML2 (H2O) 2] (M = Co, Ni, Cu and Cd) 1 ~ 4 and [ZnL2 (5), [CuL2 (py) 2] (6). The composition of the complex was determined by elemental analysis, IR, TG and other characterization methods. The crystal structures of complexes 3 and 6 were determined by single crystal X-ray diffraction The intensity and mode of their interaction with DNA were studied by using ethidium bromide fluorescent probes. The effects of ligands and complexes on the activity of E. coli JM109, E. coli DH5α, The antibacterial activities of 6 bacteria including S. epidermidis, S. aureus, baumanii and S. viridans and their antimicrobial activity against normal 293T cells and tumors In Vitro Proliferation Inhibition of Cell RAW264.72.