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目的了解哮喘患者气道阻力的变化对中枢驱动的影响。方法对13名正常人和21例哮喘患者作气道反应性测定，于激发试验前后分别测定吸气初0．1s时口腔阻断压（P_(0.1)），其中10例哮喘患者激发试验后吸入喘乐宁，测定FEV_1及P_(0.1)。结果正常人9名（9／13）、哮喘患者19例（19／21例）组胺激发试验后P_(0.1)较激发前显著升高．两组P_(0.1)且升高人数的百分比比较差异无显著性，哮喘患者激发后FEV_1％与P_(0.1)呈负相关（r＝－0．4576，P＜0．05），10例哮喘患者激发后吸入喘乐宁，FEV_1较激发后显著上升,P_(0.1)则显著下降。结论组胺诱导哮喘患者支气管收缩时，FEV_1下降，P_(0.1)上升，二者呈负相关，吸入支气管舒张剂后，FEV_1上升，P_(0.1)下降，表明中枢驱动受气道阻力的影响。
Objective To understand the effects of changes in airway resistance on central drive in asthmatic patients. Methods Airway responsiveness was measured in 13 normal subjects and 21 asthmatic patients. Before and after the challenge test, the occlusion pressure (P_ (0.1)) was measured at the first 0.1s of inhalation. After the stimulation test of 10 asthmatic patients Inhaled asthma Ning, measured FEV_1 and P_ (0.1). Results Nine (9/13) normal subjects and 19 (19/21) asthmatic patients had higher P_ (0.1) than that before challenged with histamine challenge test. There was no significant difference in the percentage of P_ (0.1) between the two groups. The percentage of FEV_1% negatively correlated with P_ (0.1) in asthmatic patients (r = -0.4576, P <0.05) Inhaled asthma after the patient inspired, FEV_1 significantly increased after challenge, P_ (0.1) decreased significantly. Conclusions When histamine induces bronchoconstriction in asthmatic patients, FEV_1 is decreased and P_ (0.1) is increased. There is a negative correlation between FEV_1 and bronchodilator. FEV_1 is increased and P_ (0.1) is decreased after bronchodilator inhalation, indicating that central driving is affected by airway resistance.