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目的:为评价T抗原检测对大肠癌普查的价值.方法;用半乳糖氧化酶-雪夫液(GO-S)方法,对166例不同对象的直肠粘液标本进行T抗原检测.结果:40例大肠癌组、33例大肠息肉组、18例结直肠炎组、56例对照组,T抗原的阳性率分别为85.0%、24.2%、11.1%和10.7%.前两者与对照组相比差异显著(P<0.01和P<0.05).结论:GO-S作大肠癌和息肉T抗原检测,具有较高的敏感性(85.0 %)和特异性(89.3 %),因此,可作为潜在的结直肠癌筛检应用,同时也为结直肠息肉筛检提供了一种方法.
OBJECTIVE: To evaluate the value of T-antigen detection in colorectal cancer screening. Methods: T-antigen detection was performed on 166 specimens of rectal mucous from different subjects using galactose oxidase-Schiff fluid (GO-S) method. Results: 40 cases of large intestine In the cancer group, 33 cases of large intestine polyposis group, 18 cases of colorectal inflammation group, and 56 cases of control group, the positive rate of T antigen was 85.0%, 24.2%, 11.1%, and 10.7%, respectively. The difference between the former two groups and the control group was significant. (P<0.01 and P<0.05). Conclusion: GO-S for colorectal cancer and polyp T antigen detection has a higher sensitivity (85.0 %) and specificity (89.3 %), and therefore, can be used as a potential colorectal The cancer screening application also provides a method for the screening of colorectal polyps.