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目的:初步了解阿里红提取物对小鼠急性毒性的强弱及特点,测定急性毒性的相关参数。方法:小鼠观察检疫3天,随机分为5组,分别为空白对照组、阿里红提取物4.82、5.70、6.67、7.85g/kg剂量组,灌胃给予阿里红提取物,观察其毒性表现。结果:阿里红提取物组随着剂量的增加,毒性反应表现越明显,小鼠死亡只数也随之增加:空白对照组动物均无异常。结论:阿里红提取物小鼠口服急毒半数致死量(LD50)为6.31g/kg;阿里红提取物可能对胃肠系统有一定的毒性作用。
OBJECTIVE: To understand the strength and characteristics of Acute Redness of Alizarin Red extract in mice and to determine the related parameters of acute toxicity. Methods: The mice were observed for quarantine for 3 days. The mice were randomly divided into 5 groups: blank control group, 4.82, 5.70, 6.67 and 7.85 g / kg dose group of Alirima extract, and the extract of Alisma orientalis . Results: With the increase of dose, the more obvious toxicity reaction occurred in the extract of Alisma orientalis, and the number of deaths in mice also increased. No abnormality was observed in the control animals. CONCLUSION: The oral LD50 of Alirima extract is 6.31g / kg. Alisma orientalis extract may have some toxic effects on the gastrointestinal system.