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目的探讨低频经颅磁刺激对儿童抑郁障碍患者认知功能及生活能力的影响。方法将60例儿童抑郁障碍患者分为2组,每组30例。对照组采用帕罗西汀治疗;实验组采用低频经颅磁刺激治疗,对比2组汉密尔顿抑郁量表(HAMD评分)、简明精神状态量表(MMSE评分)、巴塞尔指数(Barthwl指数)、儿童睡眠习惯问卷(ASHQ评分)、副反应量表(TESS评分)变化及不良反应发生情况。结果 2组疗效等级资料差异无统计学意义(P>0.05),具有可比性。实验组总有效率(93.33%)高于对照组(83.33%),差异无统计学意义(χ~2=1.455,P>0.05)。2组治疗后HAMD评分、ASHQ评分显著降低,MMSE评分、Barthwl指数显著升高(P<0.05);实验组治疗后HAMD评分、ASHQ评分显著降低,MMSE评分、Barthwl指数改善程度显著优于对照组,差异有统计学意义(t=6.451、2.306、6.319、8.819,P<0.05);实验组TESS评分(2.19±0.65)显著低于对照组(3.81±1.27),差异有统计学意义(t=6.219,P<0.05)。实验组不良反应发生率(16.67%)显著低于对照组(43.33%),差异有统计学意义(χ2=3.889,P<0.05)。结论低频经颅磁刺激能显著提高儿童抑郁障碍患者认知功能及生活能力,且不良反应发生率低。
Objective To investigate the effect of low frequency transcranial magnetic stimulation on cognitive function and life expectancy in children with depressive disorder. Methods Sixty children with depression were divided into two groups (n = 30 in each group). The control group was treated with paroxetine. The experimental group was treated with low-frequency transcranial magnetic stimulation. The Hamilton Depression Rating Scale (HAMD), Simple Mental Status Scale (MMSE), Basel’s Index (Barthwl), Children’s Sleep Habit Questionnaire (ASHQ score), changes in the side effects scale (TESS score) and adverse events. Results There was no significant difference between two groups (P> 0.05), which was comparable. The total effective rate (93.33%) in the experimental group was higher than that in the control group (83.33%), with no significant difference (χ ~ 2 = 1.455, P> 0.05). The HAMD score, ASHQ score and the MMSE score and Barthwl index of the two groups were significantly decreased (P <0.05). After treatment, the scores of HAMD and ASHQ decreased significantly in the two groups, and the scores of MMSE and Barthwl index in the experimental group were significantly better than those in the control group , The difference was statistically significant (t = 6.451,2.306,6.319,8.819, P <0.05); The TESS score of experimental group (2.19 ± 0.65) was significantly lower than that of control group (3.81 ± 1.27), the difference was statistically significant (t = 6.219, P <0.05). The incidence of adverse reactions in the experimental group (16.67%) was significantly lower than that in the control group (43.33%), the difference was statistically significant (χ2 = 3.889, P <0.05). Conclusion Low frequency transcranial magnetic stimulation can significantly improve the cognitive function and living ability of children with depressive disorder, and the incidence of adverse reactions is low.