The opioid epidemic continues to be a serious public health concern.Many have pointed to prescription drug misuse as a nidus for patients to become addicted to opioids and as such,urologists and other surgical subspecialists must critically define optimal pain management for the various procedures performed within their respective disciplines.Controlling pain following penile prosthesis implantation remains a unique challenge for urologists,given the increased pain patients commonly experience in the postoperative setting.Although most of the existing urological literature focuses on interventions performed in the operating room,there are many studies that examine the role of preoperative adjunctive pain medicine in diminishing postoperative narcotic requirements.There are relatively few studies looking at postoperative strategies for managing pain in prosthetic surgery with follow-up past the immediate hospitalization.This review assess the various strategies employed for managing pain following penile implantation through the lens of the current state of the opioid crisis,thus examining how urologists can responsibly treat pain without contributing to the growing threat of opioid addiction.