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目的:观察帕米膦酸二钠联合153钐-乙二胺四甲撑膦酸(153Sm-EDTMP)治疗多发性骨转移瘤的疗效及毒副作用。方法:53例多发性骨转移瘤患者前瞻性随机分为帕米膦酸二钠联合153Sm-EDTMP治疗组(治疗组)和单用帕米膦酸二钠治疗组(对照组),观察疗效及毒性反应。结果:治疗组和对照组的止痛有效率分别为82.1%和76.0%(P>0.05),骨转移影像缓解率分别为46.4%和20.0%(P<0.05),毒副作用差异无显著性。结论:帕米膦酸二钠联合153Sm-EDTMP治疗多发性骨转移瘤近期疗效好、毒副作用小。
Objective: To observe the curative effect and side effects of pamidronate disodium combined with 153 samarium-ethylenediamine tetramethylene phosphonic acid (153Sm-EDTMP) in the treatment of multiple bone metastases. Methods: Fifty-three patients with multiple bone metastases were prospectively randomized to receive either pamidronate disodium combined with 153Sm-EDTMP (treatment group) or pamidronate alone (control group). The efficacy and Toxic reaction. Results: The effective rates of pain relief in treatment group and control group were 82.1% and 76.0% respectively (P> 0.05). The rates of bone metastases were 46.4% and 20.0% (P <0.05), respectively. There was no significant difference in the side effects. Conclusion: Pamidronate combined with 153Sm-EDTMP in the treatment of multiple bone metastases has short-term curative effect and little toxic side effects.