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白念珠菌为现代医学最重要的机会性致病酵母菌,严重威胁着患者的生命。分泌型天冬氨酸蛋白酶是白念珠菌分泌的一种酸性蛋白酶家族,与白念珠菌毒力密切相关,由于它至少含有10个成员,各成员之间多方面的差异和错综复杂的关系给科研工作者明确白念珠菌蛋白酶的致病机制带来了困难。近年来,大量研究证实了分泌型天冬氨酸蛋白酶各成员对温度、pH值等培养方面有不同的要求,基因突变技术的发展,进一步明确了基因表达调控与机体感染部位、感染状态之间的关系及转录活化因子在蛋白酶各成员表达中的作用。
Candida albicans is the most important opportunistic pathogenic yeast in modern medicine, which seriously threatens the life of patients. Secretory aspartic proteinase is a family of acid proteases secreted by Candida albicans and is closely related to the virulence of Candida albicans. Due to its at least 10 members, many differences and intricate relationships among members, Workers have identified the pathogenesis of Candida albicans has brought difficulties. In recent years, a large number of studies have confirmed that members of the secreted aspartic protease have different requirements on temperature, pH and other culture, the development of gene mutation technology, and further clarify the relationship between gene expression and control of infection and infection sites And the role of transcriptional activators in the expression of protease members.