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保泰松引起的药物反应以血液、皮疹及胃肠道反应多见。中毒性肝肾损害合并全身剥脱性皮炎较少见。现将最近所见一例报告如下。女,63岁,退休工人,1980年4月28日抬床入院。患者因类风湿关节炎,从2月28日起在某卫生院用保泰松治疗,用量0.3～0.6克/天。用药第九天因下肢浮肿,改服中药二周而好转。因关节痛再服保泰松。于服药第25天(4月20日),先畏寒,后发热达38～39.5℃,颜面浮肿,全身皮肤出现红色斑疹、痕痒。胃纳整、烂便、尿黄。第三天出现黄疸。卫生院诊为:“病毒性肝炎及类风湿皮疹”改用复方氨基比林肌注一次,口服安乃近1.5克一天。因发热不退、症
Phenylbutazone caused by drug reactions to blood, rash and gastrointestinal reactions more common. Toxic liver and kidney damage combined exfoliative dermatitis less common. Now see a recent report as follows. Female, 63 years old, retired worker, escorted on 28 April 1980. Patients with rheumatoid arthritis, from February 28 in a hospital with phenylbutazone treatment, the amount of 0.3 to 0.6 grams / day. The ninth day of medication due to lower extremity edema, change service for two weeks and improve. Phenylbutazone for joint pain. In the first 25 days of medication (April 20), first chills, fever 38 ~ 39.5 ℃, facial edema, red skin rash, itchy. Satisfaction of the stomach, rotten stool, urine yellow. The third day jaundice. Health clinic as: “viral hepatitis and rheumatoid rash” to compound aminopyrine intramuscular injection, oral administration of nearly 1.5 grams a day. Because of fever, disease